Phd Candidate with Scientific Interest in Cancer

vor 4 Wochen


Basel, Schweiz Universität Basel Vollzeit

The Department of Biomedicine is a joint effort between the University of Basel and the University Hospitals Basel. It unites basic and clinical scientists to advance our understanding of health and disease and to develop pioneering therapies benefiting the lives of patients in areas of unmet need. With more than 70 research groups and 900 employees, the Department of Biomedicine is the largest department at the University. We are located in the heart of Basel across 6 different locations. Be part of our future

**Your position**

Our research is dedicated to dissect mechanisms of anti-tumor immune responses allowing to develop novel strategies to fight cancer. To accomplish the preclinical and clinical development of immunotherapeutic strategies against cancer, we perform experimental studies in human and murine tumor models along with translational research on clinical trials in close collaboration with the Division of Medical Oncology and larger oncology networks.
As a PhD student, you will elaborate on understanding the immunomodulatory aspects of novel immuno-oncology (IO) agents on the tumor microenvironment (TME) and develop ex vivo platforms allowing a detailed investigation on their mechanism of action. A major focus will be on:

- Develop and implement spatial omics techniques, including both transcriptomic and proteomic platforms.
- Decipher cellular mechanisms and interactions, and their significance in anti-tumor immunity, through comprehensive analyses of human material.
- Characterize the effect of IO agents on the TME by conducting immuneprofiling and analysis of soluble mediators.
- Important related publications include: Thommen et al Nat Med 2018 ; Voabil et al, Nat Med 2021; Natoli, J Immunother Cancer 2022; Kirchhammer et al Science Translational Medicine 2022_

**Your profile**
- Master's degree in the field of immunology or biomedical sciences
- Strong scientific background in immunology, preferably in the field of cancer immunology
- Ability to work independently and as a team player with excellent oral and written communication skills
- Previous experience and hands-on skills in immunological methods including primary cell culture, histology and flow cytometry. Knowledge in spatial omics techniques, bioinformatics and high-throughput data analysis is desirable.
- Highly motivated to drive projects forward and taking responsibility for experimental design, planning, execution of experiments as well as analysis and presentation of data.
- Contribute to the writing of reports and manuscripts

**We offer you**
- A highly active scientific environment in translational cancer immunology and immunotherapy
- A national and international network with numerous academic research projects and industrial collaborations
- Access to state-of-the-art facilities and translational research
- Support for presentation of work at scientific conferences and publication of scientific work.
- Integration in a PhD program at the University of Basel

**Application / Contact**
- Curriculum vitae and supporting documents such as certificates
- Letter of motivation including a concise statement of research interests
- Names of at least two referees

Please combine these documents in a single pdf file and send it by mail to
Dr. Karin Schäuble & Dr. Asmita Pant,
Lab Cancer Immunology DBM & Institute of Pathology

Submission deadline: 15th April 2024



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