Computational Toxicology Manager

We are JTI, Japan Tobacco International, and we are present in 130 countries. We have spent years innovating, creating new and better products for **the consumers to choose from**. This is our business. But not only. Our business is our people. Their talent. Their potential. We believe that when they are** free to be themselves**, and they are given the opportunity to grow, travel and develop, **amazing things can happen**.

That’s why our employees, from around the world, choose to be a part of JTI.** It is why 80% of employees feel happy working at JTI.** And why we’ve been awarded **Global Top Employer status, ten years running**.

So when you’re ready to choose a career you’ll love, in a company you’ll love, feel free to #JoinTheIdea.

**Computational Toxicology Manager**

**Position purpose**:
The Computational Toxicologist performs toxicological risk assessments of flavor substances, tobacco ingredients, NTM ingredients, packaging ingredients and other substances used in the manufacture of JTI products. In addition, the incumbent contributes to these toxicological risk assessments by developing and deploying state of the art in silico toxicological tools including scientific data handling approaches. In this context the incumbent is responsible for ensuring that global SRA business objectives, needs, and user requirements from SRA business units are transposed into systems developments, robust operational business processes and the associated maintenance thereof. The incumbent will ensure the scientific integrity of JTIs in silico toxicological tools, while testing and validating the tools in order to verify the correctness of scientific data handling, search engines, workflows and predictive models. The incumbent will be an integral part of the SRA digitalization initiative and ensures appropriate inclusion of in silico tools, closely interacting with, end users, IT BTS and the SRA Systems and Process Director, in the SRA digital landscape.

The incumbent supports the training activities of other relevant internal stakeholders and actively contributes to the external communication for example in publications, scientific conferences or in meetings with their expert network.

**What will you do - responsibilities**:
**Risk assessment and in silico Data handling and analysis**

Contribute to toxicological risk assessments of flavor substances, tobacco ingredients, NTM ingredients, packaging ingredients and other substances used in the manufacture of JTI products to ensure the scientific defensibility of products worldwide by developing and deploying state of the art in silico toxicological tools including scientific data handling approaches

**In Silico Tools and data handling - Development**

**In Silico Tools and data handling - Support for Maintenance**

Support with scientific knowledge IT BTS and SRA R&S to maintain and minimize downtime of deployed in silico solutions such as databases, pipelines, predictive models, and workflows.

**SRA Digitalization**

Partner with the SRA Systems and Process Director to develop and align a digitalization agenda to reinforce SRA digital landscape, aiming to integrate new and existing scientific data and computational methods to support pipeline programs and platform technology to ease end user adoption.

Contribute in the transition to NGRA, including handling and integration of NAMs data, acting as a Product Owner, mentoring, coaching toxicology team members, ensuring proper documentation and playing a key role in leveraging applied computational literacy within the team.

**Product Compliance and External Engagement**

Support toxicology team members in the evaluation strategies to meet regulatory requirements and submission deadlines. Perform expert assessments using toxicological prediction tools, but not limited to, cheminformatics, exposure modelling, bioinformatics, and advanced database searches. Communicate results efficiently and effectively ensuring appropriate documentation and filing of data and/or reports.

Represent JTI at meetings with external experts in the area of in silico toxicology. Actively contribute to publications, and conferences. Closely monitor competitor activities and support the development of relevant company positions.

**Risk assessment & Product Testing**

Perform toxicological risk assessments of flavor substances, tobacco ingredients, NTM ingredients, packaging ingredients and other substances used in the manufacture of JTI products or third parties, to ensure the scientific integrity of JTI products worldwide. Harmonize and standardize toxicological evaluation processes within JTI SRA function, to increase the efficiency of the toxicological review processes within the product stewardship program.

Commission the different tests required under the JTI toxicology program including liaison with contract research laboratories. Support the design and management of any JTI toxicological study.

**Who are we looking fo