Mrna - Lnp Scientist (F/m/d)

vor 2 Wochen

Basel, Schweiz Lonza Vollzeit

Switzerland, Basel- Today, Lonza is a global leader in life sciences operating across three continents. While we work in science, there’s no magic formula to how we do it. Our greatest scientific solution is talented people working together, devising ideas that help businesses to help people. In exchange, we let our people own their careers. Their ideas, big and small, genuinely improve the world. And that’s the kind of work we want to be part of.

Experienced professional and scientist in the field of formulation development for biologics / mRNA-LNP. Good evidence for delivering on commitments and working collaboratively in cross-disciplinary teams. He/she will be in charge of developing and running dedicated formulation related methods and tests, while assisting with other ongoing developments, based on defined innovation project plan. He/she plays a crucial role in the network between the different departments focusing on mRNA and LNP formulation platform development. He/she is accountable for the performance and results of the assigned projects.

**Specific accountabilities**:

- Close collaboration with principal scientists, and other associates in the team with focus mRNA formulation
- Setting up and maintenance of Innovation lab facilities
- Support of activities in mRNA Innovation, process development and/or analytical development may be requested if justifiable by extreme workloads.
- Actively participates in research and development activities, including performing research, writing of protocols, SOPs, URS, etc reporting research results in writing and verbal presentations.
- Support the development and implementation of the site quality
- May assist with purchasing and stocking of lab consumables and equipment.
- Serve as Proxy to the development units coordinator upon request of leadership.
- Support the unit Head in the implementation of lab operational and logístical activities
- Execution of mRNA encapsulation into lipid nanoparticles (LNPs), Chromatography and Tangential Filtration operations along with related analytical techniques
- Act as a trainer of new staff and coworkers in the expertise units of operation.
- Work via DoE approach and statistical evaluation of data
- Ensuring developed methods meet requirements, potentially also for GMP/QC environment
- Act as a trainer of new staff and coworkers in the expertise units of operation.

**Generic accountabilities**:

- Provide solutions to identified risks, issues, problems. Report issues in a timely fashion.
- Facilitate improvements to departmental business processes and contribute to the implementation of innovative technologies.
- Demonstrate flexibility to support other activities within the department.
- Proactive approach to own continuous professional development.
- Prepare oral and written reports to communicate scientific findings and to support project documentation and CMC submissions.
- Comply with data integrity requirements for laboratory work.

**Key requirements**:

- M.Sc. / phd within Biotechnology, bioengineering, chemical engineering, analytical chemistry
- Experience in formulation development for biomolecules, with preference experience with mRNA formulation in lipid nanoparticles
- Expert-level experience & understanding of handling, purification and processing of biomolecules.
- Experience in mRNA is preferred but not essential.
- Experience with chromatographic methods and TFF systems is highly preferred.
- Demonstrated ability to efficiently work in a fast paced and fluid environment, changes in priority and timeline restrictions
- Knowledge of technology transfer and GMP manufacturing an advantage
- Pilot Scale: Purification techniques using pilot scale equipment, single-use systems, scale-up, process consistency, process control strategy
- Strong written and verbal communication skills including good command of English language.Preferred Qualifications (This would be a plus):

- Understanding of purification of biologics, specifically large size mRNA & LNP, including process scale-up.
- Hands-on experience with a wide range of purification, formulation and analytical techniques for large nucleic acid molecules including affinity capture, ion exchange and hydrophobic interactions.
- Design and execute DOE studies & high-throughput screen for purification process improvements and advancements

Every day, Lonza’s products and services have a positive impact on millions of people. For us, this is not only a great privilege, but also a great responsibility. How we achieve our business results is just as important as the achievements themselves. At Lonza, we respect and protect our people and our environment. Any success we achieve is no success at all if not achieved ethically.

People come to Lonza for the challenge and creativity of solving complex problems and developing new ideas in life sciences. In return, we offer the satisfaction that comes with improving lives all around the world. The satisfaction

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