Postdoc Position

vor 2 Wochen

Lausanne, Schweiz Université de Lausanne Vollzeit

**Introduction**:
UNIL is a leading international teaching and research institution, with over 5,000 employees and 17,000 students split between its Dorigny campus, CHUV and Epalinges. As an employer, UNIL encourages excellence, individual recognition and responsibility.

**Presentation**:
Postdoc Position - University of Lausanne, Department of Biomedical Sciences, Paolicelli Lab
We are looking for a highly motivated postdoctoral researcher to study the role of TDP-43 in the control of microglial function.

Microglia, the innate immune cells of the central nervous system, play important functions in the healthy as well as in the diseased brain. Several genes associated with neurodegeneration are highly expressed in microglia, and recent evidence suggests that these cells can critically influence the onset and course of brain diseases. However, the underlying cellular mechanisms are not entirely clear. In this project, we will investigate the role of the DNA-RNA binding protein TDP-43, as a modulator of different microglial functions. In particular, we will focus on the effects on phagocytic capacity and lipid metabolism

**Job information**:
Expected start date in position : 01.09.2024

Contract length : 1 year with possibility of renewal

Activity rate : 100%

Workplace : Lausanne, Rue du Bugnon 7

**Your responsibilities**:
The project aims at investigating how the loss of function of TDP-43, selectively in microglia, affects lipid metabolism and myelination in pathological models (demylination induced by LPC). We will combine in vivo (TDP-43 microglial cKO mice) and ex vivo/in vitro models (organotypic slices and primary microglia cultures) with biochemical and histological approaches, confocal imaging, lipidomics and sc-RNA sequencing.

**Your qualifications**:

- Full habilitation to work with animals is a must.
- Expertise in microglia biology and lipid metabolism is highly appreciated.

**What the position offers you**:
The University of Lausanne is a higher teaching and research institution composed of seven faculties where approximately 15,000 students and nearly 5,000 collaborators, professors, and researchers work and study. Ideally situated along the lake of Geneva, near Lausanne’s city center, its campus brings together over 120 nationalities.

**Contact for further information**:
Prof. Paolicelli

Deadline : 30.06.2024

We thank you for your understanding.

**Additional information**:

- UNIL is committed to equal opportunities and diversity._
- UNIL supports early career researchers._

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