Phd Position
vor 2 Monaten
As of December 2023 or by arrangement, the Institute of Virology and Immunology (IVI) at the Vetsuisse campus in Bern, Switzerland, is recruiting a PhD student to work on the immune system of dogs.
In the Comparative Immunology group, we focus on the mononuclear phagocyte system
- a network of highly versatile innate immune cells that is central for orchestrating immunity. We envision that insights from multiple species will lead to a more comprehensive understanding of the system's evolutionary or key functions and reveal novel approaches for improved immunotherapies and vaccines, in both the target species and beyond. With single-cell RNA sequencing (scRNA-seq), we have a powerful tool at hand to perform these comparative analyses, while directly promoting scientific and medical progress in the investigated species itself.
Tasks
In the present PhD project, we will explore the heterogeneity of dendritic and monocytic cells in dogs, based on our recent work in cattle (link to publications). Our primary goal is to create a canine immune-cell atlas which is urgently needed for clinical research to properly study and treat immune-mediated diseases of dogs. To account for the comparative aspect, we plan to incorporate this work into a bigger project, where the mononuclear phagocyte system will be studied in various species including pig, goat, and sheep, but also mouse and human. Laboratory techniques will encompass immune-cell isolation from blood and tissues, high-parameter flow cytometry, magnetic
- and fluorescence-activated cell sorting, cell stimulation assays, metabolic assays, as well as bulk
- and scRNA-seq.
**Requirements**:
The PhD student will be integrated into the Graduate School for Cellular and Biomedical Sciences (GCB) at the University of Bern, and receive in-depth training in Immunology and key laboratory techniques, such as high-parameter flow cytometry. Through the analysis of scRNA-seq data, the PhD student will develop good bioinformatic skills, while receiving support from bioinformaticians on site.
You have a master's degree in Veterinary Medicine, Biology, or related fields, and are excited by the idea of exploring big datasets for making discoveries?
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