3 Phd Student Positions in Chemical Protein

vor 5 Monaten

Zurich, Schweiz Department of Chemistry Vollzeit

Department of Chemistry_
**3 PhD Student Positions in Chemical Protein Synthesis**
**80 % **:Three PhD student positions are available in the group of Prof. Dr. Nina Hartrampf in the Department of Chemistry at the University of Zurich (Switzerland). The group is using flow chemistry for the chemical synthesis and modification of peptides and proteins. As part of the collaborative and interdisciplinary SNSF Sinergia Project “MYConnect” we will investigate the role of phosphorylation-dependent MYC interactions in cancer biology. We will develop new synthetic methodology to prepare synthetic MYC analogues in order to characterize their binding interactions in biophysical assays.

**Your responsibilities**: This interdisciplinary project combines a variety of disciplines and tools in the broader field of chemical protein synthesis and chemical biology. You will design, synthesize and modify MYC derivatives using our state-of-the-art fully automated synthesis platform and ligation technologies. You will be driving the characterization of chemically synthesized proteins using various analytical techniques (UHPLC, LCMS, NMR, CD, etc.). To elucidate their biological role and function, you will work with biochemical, biophysical, and cellular assays to analyze and quantify the binding interactions between the oncoprotein MYC (and derivatives thereof) and its binding partner(s).

**What we offer**: We offer three exciting PhD positions in a stimulating and challenging environment at the interface of chemistry and biology. You will be trained in state-of-the-art SPPS technology, ligation techniques, protein purification and analysis, chemical biology and organic chemistry. Together with our collaborators, you will explore the role of MYC phosphorylation in cancer progression through biophysical and cellular assays. With this joint research project you will be part of an interdisciplinary and international research collaboration.

**Place of work**: University of Zurich Irchel, Winterthurerstrasse 190, Zürich, Switzerland
- letter of motivation
- curriculum vitae
- short summary of past research accomplishments
- transcripts of your academic records from your University, and a copy of your degree
- contact details of two referees (e.g. your M.Sc. thesis supervisor)

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