Role of Ros in The Pathophysiology of Osteoarthritis

vor 3 Wochen

Geneve, Schweiz Faculté de Médecine - Université de Genève - Suisse Vollzeit

**Role of ROS in the pathophysiology of osteoarthritis**:

- Réf
- **ABG-114814**
- Sujet de Thèse- 28/05/2023- Autre financement public- Faculté de Médecine - Université de Genève - Suisse- Lieu de travail- Geneve - Suisse- Intitulé du sujet- Role of ROS in the pathophysiology of osteoarthritis- Champs scientifiques- Biologie
- Santé, médecine humaine, vétérinaire
- Mots clés- ROS, NADPH oxidase, cartilage, osteoarthritis, mice**Description du sujet**:
**PhD position in osteoarthritis research**

Applications accepted between: 01 Nov 2023 - 31 Oct 2027

**Organization**: Department of Orthopedic Surgery, University Hospital & Faculty of Medicine

**Location**:University Medical Center, Geneva, Switzerland

**Job description**:
The Cell Therapy & Musculoskeletal Disorders Laboratory, Department of Orthopedic Surgery,

Geneva University Hospital has a position available for a highly motivated PhD student to

study the role of ROS in the pathophysiology of osteoarthritis.

The PhD student will investigate the role of NADPH oxidase 4 (NOX4) in the pathophysiology

chondrocyte proliferation, cell cycle analysis, inflammation, chondrocyte differentiation,

chondrocyte metabolism, culture of cartilage explants, generation and breeding of

genetically-modified mice, and induction of osteoarthritis in mice followed by histological and

morphological evaluation by micro-CT.

**Qualifications**:Master of science degree is mandatory.

Preference will be given to those individuals who have demonstrated experience in

molecular biology, flow cytometry, advanced microscopy, histological techniques including

immunohistochemistry, immunofluorescence, western blot, micro-CT image reconstruction

and analysis.

technical and competitive challenges, as well as to participate effectively in team efforts.

**Contract**:PhD position for four years, expected to start, if possible, November 1st 2023. Pay

is according to the rules of the Swiss National Science Foundation. Student will be enrolled in

the PhD School of Life Sciences at the Faculties of Medicine at the University of Geneva.
- Your Curriculum Vitae.
- The names and addresses of 2 referees.
- A letter of reference.

**Prise de fonction**:

- 01/11/2023**Nature du financement**:

- Autre financement public**Précisions sur le financement**:
**Présentation établissement et labo d'accueil**:

- Faculté de Médecine - Université de Genève - Suisse**Location**: Faculté de médecine de l'Université de genève

Our research group is involved in basic and translational research in the field of osteoarthritis (OA), led by Pr Didier Hannouche, and in the field of skeletal muscle stem cells (MuSC), led by Dr Thomas Laumonier.

In OA, articular cartilage follows a progressive degeneration, where low-grade inflammation could play a pivotal role through an oxidative stress-dependent mechanism and exposure to reactive oxygen species (ROS). We hypothesize that ROS production by chondrocytes through NADPH isoform 4 (NOX4), plays a noxious role in OA pathogenesis. For this purpose, we investigate the implication of NOX4 in the pathophysiology of OA, both in vivo and in vitro.

The laboratory has also a long experience in the isolation, culture, characterization, and transplantation of human MuSC. The research work focuses mainly on the development of cell therapy strategies in the treatment of skeletal muscle disorders, including myopathies. We demonstrated that human muscle reserve cells (MuRC), generated in vitro, are like quiescent MuSC with properties required for their use in cell therapy. The objective of the ongoing studies is to characterize the molecular signature, the metabolic profile of human MuRC and to identify new mechanisms that regulate the function of these cells in vitro and in vivo.

**Site web**:
**Intitulé du doctorat**:

- PhD**Pays d'obtention du doctorat**:

- Suisse**Etablissement délivrant le doctorat**:

- UNIGE**Ecole doctorale**:

- Life Sciences, Geneva University**Qualifications**:Master of science degree is mandatory.

Preference will be given to those individuals who have demonstrated experience in

molecular biology, flow cytometry, advanced microscopy, histological techniques including

immunohistochemistry, immunofluorescence, western blot, micro-CT image reconstruction

and analysis.

technical and competitive challenges, as well as to participate effectively in team efforts.- 31/08/2023

  • Consultant, Support to The Development of Campaign

    vor 4 Wochen

    Geneve, Schweiz International Federation of Red Cross and Red Crescent Societies Vollzeit

    **Vacancy No.** S05470 **Contract Type** Consultant **Application Deadline** 04-Feb-2024 **Job Posted on** 24-Jan-2024 **Country** GLOBAL Different Locations **Duty Station** Global **Duration** An estimate of 50 working days for 8 months, from 01 March 2024 to 30 September 2024 **Grade** Consultant, Not Applicable **Organizational...

  • Consultant for The Mandate of The Independent

    vor 4 Wochen

    Geneve, Schweiz United Nations Vollzeit

    **Job Opening** **Job Opening ID**: 226312 **Job Network** : Political, Peace and Humanitarian **Job Family** : Human Rights Affairs **Category and Level** : Consultants, CON **Duty Station** : GENEVA **Department/Office** : Office of the High Commissioner for Human Rights **Date Posted** : Jan 22, 2024 **Deadline** : Feb 22, 2024 **Result of...

  • Master of Advanced Studies in Sport Management

    vor 4 Wochen

    Geneve, Schweiz AISTS International Academy of Sports Science and Technology Vollzeit

    The primary mission of AISTS is to master sport by positively contributing to sports management through a multidisciplinary approach to education and sciences and by remaining at the forefront of the sports industry’s development and the Olympic movement’s evolution. The AISTS focuses its activities around three pillars: - Education Applied Research...

  • Lead, Business Engagement Shaping The Future of

    Vor 4 Tagen

    Geneve, Schweiz World Economic Forum LLC Vollzeit

    The World Economic Forum, committed to improving the state of the world, is the international organization for public-private cooperation. The Forum engages the foremost political, business and other leaders of society to shape global, regional and industry agendas. Why we are recruiting The World Economic Forum _Centre for Regions, Trade, and...

  • Full or Associate Professor in The Field of

    Vor 4 Tagen

    Geneve, Schweiz Springer Nature Vollzeit

    **FULL or ASSOCIATE PROFESSOR in the field of bioinformatics**: - Employer- University of Geneva (UNIGE)- Location- Geneva, Canton of Geneva (CH)- Salary- competitive- Closing date- 8 Mar 2024- Discipline Computing, Health Science, Life Science Job Type Faculty Member Employment - Hours Full time Duration Permanent Qualification PhD Sector ...

  • Head of Operations

    Vor 7 Tagen

    Geneve, Schweiz Adecco Human Resources AG Vollzeit

    Critères de l'offre **L'entreprise**: LHH The Adecco Group Switzerland Description du poste For one of our client, a well-established Financial Services Company, we are actively looking for a Head of Operations based in Geneva. **Responsabilities**: In connection with the banks, lawyers, Private Banks and other service providers, you will: Set-up,...

  • Head of People Services

    vor 4 Wochen

    Geneve, Schweiz World Economic Forum LLC Vollzeit

    The World Economic Forum, committed to improving the state of the world, is the international organization for public-private cooperation. The Forum engages the foremost political, business, and other leaders of society to shape global, regional, and industry agendas. Why we are recruiting: In line with our commitment to organizational excellence, we are...

  • Head Curator, in Charge of The Research and

    Vor 6 Tagen

    Geneve, Schweiz Ville de Genève Vollzeit

    Afin de compléter son équipe, le Muséum d'histoire naturelle de la Ville de Genève recherche un ou une HEAD CURATOR, in charge of the RESEARCH AND COLLECTIONS UNIT (100%). Entrée en fonction: to be agreed Délai d’inscription: 22.09.2023 Rattachement: Muséum d'histoire naturelle **Votre mission et vos responsabilités**: As Head Curator in charge...

  • Head of Management Accounting

    Vor 5 Tagen

    Geneve, Schweiz PICTET Vollzeit

    **Your team**: - Corporate Functions includes the Group’s non-banking activities and employs more than 600 people. These functions are carried out by specialists with expertise across all business units, and include the Communications, Compliance, Finance, Human Resources, Information Security, Internal Audit, Legal, Organisation, Risk and Tax...

  • Head of Transaction Monitoring

    Vor 4 Tagen

    Geneve, Schweiz Lombard Odier & Cie Vollzeit

    A career at the Lombard Odier Group is something to be proud of. Our mission is to protect and grow our clients’ wealth - but not by any means necessary. Sustainability is at the heart of everything we do and we treat our clients’ wealth as if it were our own. We protect our clients’ assets for the long-term using expertise and innovation, all...

  • Head of Industry Analysis

    vor 4 Wochen

    Geneve, Schweiz International Air Transport Association (IATA) Vollzeit

    Employment Type: Permanent Contract Duration: About the team you are joining IATA Sustainability and Economics’ core objectives are to contribute to airlines’ financial sustainability and advance the industry towards the goal of net-zero CO2 emissions by 2050. In this capacity, we provide our airline members with sustainability and economic analyses,...

  • Legal Consultant to Support The Implementation of

    vor 4 Wochen

    Geneve, Schweiz United Nations Vollzeit

    **Job Opening** **Job Opening ID**: 232515 **Job Network** : Economic, Social and Development **Job Family** : ENV **Category and Level** : Consultants, CON **Duty Station** : GENEVA **Department/Office** : United Nations Environment Programme **Date Posted** : Apr 17, 2024 **Deadline** : Apr 28, 2024 **Result of Service** - The consultant is...

  • Head of Outreach and Engagement

    Vor 4 Tagen

    Geneve, Schweiz Dansk Flygtningehjælp Vollzeit

    Department **Switzerland** Workplace **Geneva** Contract Type **National contract** Posted **31 Oct 2023** Expires **19 Nov 2023** The H2H Network seeks a dynamic, ambitious, and accomplished Head of Engagement and Outreach to lead the network's expanding efforts to engage the H2H membership and amplify our work in the wider sector, championing H2H...

  • Head of Financial Institutions Management

    Vor 4 Tagen

    Geneve, Schweiz PICTET Vollzeit

    **Your team**: - Corporate Functions includes the Group’s non-banking activities and employs more than 600 people. These functions are carried out by specialists with expertise across all business units, and include the Communications, Compliance, Finance, Human Resources, Information Security, Internal Audit, Legal, Corporate Office, Risk and Tax...

  • Head of Client Relationship Management

    vor 4 Wochen

    Geneve, Schweiz BCP – BANQUE DE COMMERCE ET DE PLACEMENTS Vollzeit

    Established in 1963 as a Swiss bank, bcp.bank segments its activities into two well-established core businesses: Commodity _ - Trade Finance and Wealth Management. These are reinforced by our expert Treasury services. bcp.bank enjoys a solid _ - reputation as a high-quality service provider in all of its banking fields. Founded under Swiss Banking Law and...

  • Attorney at Law in The Area of Litigation

    vor 4 Wochen

    Geneve, Schweiz Bär & Karrer AG Vollzeit

    in Geneva Do you prefer playing in the top league of business law firms or working in a cooperative atmosphere? At Bär & Karrer you don't have to choose. Here you will find exciting tasks and outstanding team spirit. With our headquarters in Zurich and offices in Geneva, Lugano, Zug and Basel we are represented in Switzerland's main language regions. This...

  • Head of Risk

    vor 4 Wochen

    Geneve, Schweiz IQ-EQ Vollzeit

    Company Description IQ-EQ is a leading Investor Services group which combines global expertise with an unwavering focus on client service delivery. We support fund managers, global companies, family offices and private clients operating worldwide. **Job Description**: **Responsibilities (how we will measure success)**: - To deliver the agreed strategy...

  • Head of Mortgage Credit

    vor 4 Wochen

    Geneve, Schweiz Finders SA Vollzeit

    **Client**: Leading and long-established Swiss bank with a very strong presence across Switzerland as well as globally. They offer bespoke private banking services to its HNW and UHNW clients as well as being strong on corporate banking and asset management. A very stable bank with excellent reputation. In addition, they offer a friendly and dynamic place to...

  • Financial Controller

    vor 4 Wochen

    Geneve, Schweiz British School of Geneva Vollzeit

    **Description** **Financial Controller, Switzerland** **Purpose of Role** The Financial Controller, Switzerland is responsible for ensuring all financial information is controlled and accurately reported, in accordance with strict deadlines, to satisfy all internal and external reporting requirements for all legal entities in Switzerland, including...

  • Head of Global Risks Initiative

    Vor 5 Tagen

    Geneve, Schweiz World Economic Forum LLC Vollzeit

    The World Economic Forum, committed to improving the state of the world, is the international organization for public-private cooperation. The Forum engages the foremost political, business, cultural and other leaders of society to shape global, regional and industry agendas. Why we are recruiting The Centre for the New Economy and Society provides a...