4 Phd Positions in Inhibitor Design Against

vor 3 Wochen

Bern, Schweiz Universität Bern Vollzeit

As part of our Sinergia project DISPERSE (Designing Inhibitors Against Clostridial Pore-Forming Toxins: A Structure-Based Approach) 4 PhD student positions are available, in the laboratories of Profs. J.L. Reymond (Department of Chemistry, Biochemistry and Pharmaceutical Sciences, Science Faculty), B. Zuber (Institute of Anatomy; Medical Faculty) and H. Posthaus (Institute of Animal Pathology; Vetsuisse Faculty).

**Project Information**
Bacteria of the genus Clostridium cause severe animal and human diseases. β-Pore forming toxins (βPFTs) form a major group of their virulence factors. They are secreted by different pathogenic clostridia and cause cell damage by forming pores in the plasma membrane of host cells. βPFTs share common structures and molecular mechanisms, making them attractive targets for the development of anti-virulence therapies. In a collaborative research approach between three faculties at the University of Bern, we aim to design and validate peptide inhibitors against clostridial βPFTs using a combination of computational peptide design and structural knowledge of the toxins.

Tasks

**Two PhD student positions **are available in the

**Requirements**:
We are looking for motivated students with a strong interest in mechanisms of disease, molecular, cellular and structural biology as well as biochemistry and computational peptide design. The positions require a master degree in biochemistry, biology, biomedical sciences, veterinary medicine, medicine or a related field.

We offer

an enthusiastic, inspiring, international and highly collaborative research environment as well as state-of-the art research facilities at an attractive working location in Bern. These 4-year positions are available as of April 1st 2024 or by agreement. Salary and terms of employment will be in accordance with the SNSF.
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