Principal Scientist I/ii

vor 7 Stunden

Basel, Schweiz Novartis Vollzeit

6000+ The number of scientists in the Novartis Institutes for BioMedical Research (NIBR). The Musculoskeletal Disease Area (MSD) at the Novartis Institutes for Biomedical Research (NIBR) is investing in the discovery of novel and transformative therapies for patients affected by neuromuscular, tendon and cartilage diseases.
- As part of this effort, MSD is seeking an innovative and highly motivated Principal Scientist to develop, shape and advance novel therapies aimed at prevention and regeneration of neuromuscular, cartilage and tendon diseased tissues.
- You will be responsible for leading a state-of-the-art laboratory of experienced scientists, employing ground-breaking technologies to explore disease mechanisms and pathways, identify novel targets, mechanistically dissect their function and provide detailed characterization of mechanism of action of novel molecules, to enable progression of the drug discovery pipeline. This will include the use of complex in vitro assays, patient relevant cellular and ex vivo model systems to evaluate innovative therapeutic modalities (small molecules, biologics, gene therapies) with potential for long-term impact on the disease course.
- As a member of the NIBR community, you will also contribute to and benefit from a highly interdisciplinary and collaborative global community with extensive know how and resources in data sciences, chemistry, biologics, cell and gene therapy as well as chemical biology.
- Your responsibilities will include- Contribute to and/or lead early drug discovery projects within multidisciplinary teams up to clinical proof-of-concept studies in patients
- Define and execute on innovative scientific strategies, test novel disease-relevant hypotheses and develop transformative therapies
- Design and conduct experiments to address key scientific questions for various project, develop disease-relevant cellular systems with phenotypical and functional readouts using cutting-edge technologies to decipher biology of novel targets
- Closely collaborate with scientists, clinicians, and technology experts across different departments in the global organization
- Guide, supervise and develop scientific associates
- Present concepts and projects in a clear, scientifically sound, and data-driven, objective manner in different settings and venues
- Manage lab resources in a flexible manner to adapt to changing priorities

**Commitment to Diversity & Inclusion**:

- Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve._

**Minimum requirements**
- What you will bring to the role:
- PhD + a minimum of 3-5 years of relevant research experience in an academic setting and/or in the pharmaceutical/biotech sector, ideally with focus in molecular biology, biochemistry, cell biology in musculoskeletal diseases relevant areas
- Experience in target identification, validation and working with primary cells, or establishing cellular assays, or extensive cellular signaling experience, with an emphasis on disease pathways would be helpful
- Experience in biochemistry, in molecular and cellular biology to decipher the biology of novel targets and at establishing physiologic assays using human or iPS-derived patient cells, with functional or phenotypical readouts
- Experience in cutting-edge novel therapeutic approaches (e.g. gene-, RNA/DNA- or cell-therapy, complex biologics modalities, etc)
- Significant scientific accomplishments and successful collaborations documented by publications in high-impact journals
- Aptitude to work and thrive in cross disciplinary teams, coupled to good organization, communication, presentation and analytical skills.
- Proactive and dynamic attitude with a demonstrable inquisitive mindset and a proven ability to formulate, articulate, and critically evaluate data driven scientific hypotheses and build next steps. Outstanding learning agility.

Desirable requirements:
- In-depth knowledge of complex human culture systems interrogated for regeneration potential.
- Experience in translational science, data science and/or biomarkers identification would be a plus.

Why consider Novartis?
- 769 million. That’s how many lives our products touched in 2020. And while we’re proud of that fact, in this world of digital and technological transformation, we must also ask ourselves this: how can we continue to improve and extend even more people’s lives?
- We believe the answers are found when curious, courageous and collaborative people like you are brought together in an inspiring environment. Where you’re given opportunities to explore the power of digital and data. Where you’re empowered to risk failure by taking smart risks, and where you’re surrounded by people who share your determination to tackle the world’s toughest medical challenges.
- Imagine what you could do at NovartisJoin our Novartis Network:

- If this role is not suitable

  • Principal Scientist I- Biomarker Development

    Vor 6 Tagen

    Basel, Schweiz CTC Resourcing Solutions Vollzeit

    **Principal Scientist Biomarker Development (5470 - LBD)** Our client, an innovative and dynamic bio-pharmaceutical company headquartered in Switzerland, covering multiple therapeutic areas, is looking for a **Principal Scientist Biomarker Development **for a 8** month contract role **with the possibility of extension** based in Basel,...

  • Research Scientist I/ii

    Vor 3 Tagen

    Basel, Schweiz Novartis Vollzeit

    6000! That’s the number of associates in the Novartis Institutes for BioMedical Research (NIBR). This division is the innovation engine of Novartis, focusing on powerful new technologies that have the potential to help produce therapeutic breakthroughs for patients. - The department for Autoimmunity, Transplantation and Inflammation (ATI) within NIBR is...

  • Principal Scientist

    vor 7 Stunden

    Basel, Schweiz Batterman Consulting Basel AG Vollzeit

    **Our Client** **Principal Scientist****: **Your responsibilities** - Provide key biology expertise and leadership for defined programs throughout discovery and development stages - Identify and design experimental work plans to address program needs at various stages - Participation in scientific review and assessment of potential new and/or existing...

  • Principal Scientist Ii

    vor 7 Stunden

    Basel, Schweiz Novartis Vollzeit

    Location: Onsite, Basel, Switzerland #onsite The Neuroscience Department within the Novartis Institutes for Biomedical Research (NIBR) in Basel, Switzerland, is looking for a motivated and innovative PhD-level Principal Scientist with demonstrated expertise in neuroscience/neuroimmunology. Vision and Purpose of this role: The associate will provide strategic...

  • Research Scientist I or Ii

    Vor 7 Tagen

    Basel, Schweiz Novartis Vollzeit

    **Research Scientist I or II - Cellular immunology lab, Novartis, Basel, Switzerland** 6000! That’s the number of associates in the Novartis Institutes for Biomedical Research (NIBR). This division is the innovation engine of Novartis, focusing on powerful new technologies that have the potential to help produce therapeutic breakthroughs for patients....

  • Principal Scientist, Machine Learning

    Vor 3 Tagen

    Basel, Schweiz F. Hoffmann-La Roche AG Vollzeit

    Principal Scientist, Machine LearningApply locations Basel time type Full time posted on Posted Yesterday job requisition id 202411-129178Roche fosters diversity, equity and inclusion, representing the communities we serve. When dealing with healthcare on a global scale, diversity is an essential ingredient to success. We believe that inclusion is key to...

  • Research Scientist I/ii

    Vor 5 Tagen

    Basel, Schweiz Novartis Vollzeit

    6000! That’s the number of associates in the Novartis Institutes for BioMedical Research (NIBR). This division is the innovation engine of Novartis, focusing on powerful new technologies that have the potential to help produce therapeutic breakthroughs for patients. - The department for Autoimmunity, Transplantation and Inflammation (ATI) within NIBR is...

  • Principal Scientist, Machine Learning

    Vor 3 Tagen

    Basel, Schweiz F. Hoffmann-La Roche AG Vollzeit

    Principal Scientist, Machine Learning Candidatar-se locations Basel time type Tempo integral posted on Publicado ontem job requisition id 202411-129178 Roche fosters diversity, equity and inclusion, representing the communities we serve. When dealing with healthcare on a global scale, diversity is an essential ingredient to success. We believe that inclusion...

  • Principal Research Engineer/Scientist

    vor 1 Woche

    Basel, Schweiz Roche Vollzeit

    Roche fosters diversity, equity and inclusion, representing the communities we serve. When dealing with healthcare on a global scale, diversity is an essential ingredient to success. We believe that inclusion is key to understanding people’s varied healthcare needs. Together, we embrace individuality and share a passion for exceptional care. Join Roche,...

  • Principal Research Engineer/Scientist

    vor 1 Woche

    Basel, Schweiz F. Hoffmann-La Roche Gruppe Vollzeit

    Roche fosters diversity, equity and inclusion, representing the communities we serve. When dealing with healthcare on a global scale, diversity is an essential ingredient to success. We believe that inclusion is key to understanding people’s varied healthcare needs. Together, we embrace individuality and share a passion for exceptional care. Join Roche,...

  • Principal Data Scientist

    Vor 2 Tagen

    Basel, Schweiz Bank For International Settlements Vollzeit

    The Bank for International Settlements (BIS) is hiring a Principal Data Scientist to join our Customer & Asset Management Applications team in the Banking department. **Purpose of the job**: Through a combination of business and technical expertise, to perform and enable advanced analytics involving Banking data products. **By joining the team, you...

  • Sr Principal Analytical Development Scientist

    vor 7 Stunden

    Basel, Schweiz Proclinical Vollzeit

    Proclinical is seeking to hire a Senior Principal Analytical Development Scientist based in Switzerland with a global partner to biotech and pharmaceutical markets. **Responsibilities**: Lead the development and implementation of technical advancement and efficiency improvement within the Analytical Development (AD) function of DPS Drive technical and...

  • Dipl. Pflegefachfrau

    vor 1 Tag

    Basel, Schweiz Joker Personal AG Vollzeit

    Job **Dipl. Pflegefachfrau (HF / FH / DN I & II / AKP) Morgendienst (20-40%)**: Bereich **Gesundheits-/Sozialwesen**: Region **Region Basel**: Pensum **Festanstellung**: Eintritt **nach Vereinbarung**: Job-ID **184334-2**: **Aufgabenbereich**: Unterstützungbedürftige Kunden werden von Ihnen im ambulanten Bereich betreut Kunden erhalten vor Ort ihre...

  • Dipl. Pflegefachfrau

    vor 1 Tag

    Basel, Schweiz Joker Personal AG Vollzeit

    Job **Dipl. Pflegefachfrau (HF / FH / DN I & II / AKP) Wochenende (20-40%)**: Bereich **Gesundheits-/Sozialwesen**: Region **Region Basel**: Pensum **Festanstellung**: Eintritt **nach Vereinbarung**: Job-ID **184334-3**: **Aufgabenbereich**: Unterstützungbedürftige Kunden werden von Ihnen im ambulanten Bereich betreut Kunden erhalten vor Ort ihre...

  • Principal Scientist, Machine Learning

    Vor 3 Tagen

    Basel, Schweiz Roche Vollzeit

    Roche fosters diversity, equity and inclusion, representing the communities we serve. When dealing with healthcare on a global scale, diversity is an essential ingredient to success. We believe that inclusion is key to understanding people’s varied healthcare needs. Together, we embrace individuality and share a passion for exceptional care. Join Roche,...

  • Principal Quantitative Scientist, RWD

    Vor 6 Tagen

    Basel, Schweiz F. Hoffmann-La Roche AG Vollzeit

    Principal Quantitative Scientist, RWDRoche fosters diversity, equity and inclusion, representing the communities we serve. When dealing with healthcare on a global scale, diversity is an essential ingredient to success. We believe that inclusion is key to understanding people’s varied healthcare needs. Together, we embrace individuality and share a passion...

  • Principal Research Engineer/Scientist

    Vor 2 Tagen

    Basel, Schweiz Roche Vollzeit

    Roche fosters diversity, equity and inclusion, representing the communities we serve. When dealing with healthcare on a global scale, diversity is an essential ingredient to success. We believe that inclusion is key to understanding people’s varied healthcare needs. Together, we embrace individuality and share a passion for exceptional care. Join Roche,...

  • Principal Scientist, Machine Learning

    Vor 3 Tagen

    Basel, Schweiz F. Hoffmann-La Roche Gruppe Vollzeit

    Roche fosters diversity, equity and inclusion, representing the communities we serve. When dealing with healthcare on a global scale, diversity is an essential ingredient to success. We believe that inclusion is key to understanding people’s varied healthcare needs. Together, we embrace individuality and share a passion for exceptional care. Join Roche,...

  • Senior Principal Data Scientist

    Vor 6 Tagen

    Basel, Schweiz F. Hoffmann-La Roche AG Vollzeit

    Senior Principal Data ScientistApply locations Basel Welwyn time type Full time posted on Posted 2 Days Ago time left to apply End Date: January 21, 2025 (4 days left to apply) job requisition id 202411-128883Roche fosters diversity, equity and inclusion, representing the communities we serve. When dealing with healthcare on a global scale, diversity is an...

  • Principal Scientist in High Throughput Biology

    Vor 2 Tagen

    Basel, Schweiz Novartis Vollzeit

    Therefore, we are seeking a highly motivated, passionate scientist to join our team in the global High Throughput Biology (gHTB) group within the Chemical Biology and Therapeutics (CBT) department in Basel, Switzerland. - You will be working in an open, interdisciplinary, and collaborative environment with assay & screening biologists, data scientists,...