Phd Student Position

vor 2 Wochen


Bern, Schweiz Universität Bern Vollzeit

**Workplace**: Department of Ophthalmology, Inselspital, University of Bern
**Project Title**: Organoid-based modelling of human retinal degeneration / regeneration

The Department of Ophthalmology is offering a PhD student position in the field of neuroscience/cell biology. The group's research interest is focused on the pathophysiology of the retina. The newly opened project includes the implementation of human retinal organoids for this field of research. Thereby, two projects are combined in order to utilize the multiple possibilities of this 3D cell culture approach. Firstly, characterization of an involvement of Müller cells (MCs) in retinal degeneration / regeneration using an established human retinal organoid model is planned. This includes visualization of pathophysiological changes (immunohistochemistry) and measurements of functional alterations (3D MEA) and their active correction.

Secondly, retinal organoids will be generated from patient-derived iPSCs to study disease mechanisms in inherited retinal diseases by biochemical and molecular techniques, including RNA expression studies and CRISPR-mediated gene editing.

Requirements

Application

**Entrance**: upon Agreement

Interested applicants are invited to send their CV and the names and contact information of two referees.

**Contact Address**
Profs. Volker Enzmann & Pascal Escher

Universitätsklinik für Augenheilkunde

Inselspital

Universität Bern

Freiburgstrasse 14

3010 Bern


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