Bioinformatics Manager

At JTI we celebrate differences, and everyone truly belongs. **46,000 people from all over the world** are continuously building their unique success story with us.** 83% of employees feel happy **working at JTI.

To make a difference with us, all you need to do is bring your **human best.**

**Bioinformatics Manager**:
The Bioinformatics Manager contributes to toxicological risk assessments of flavor substances, tobacco ingredients, NTM ingredients, packaging ingredients, and other substances used in the manufacture of JTI products by developing and deploying state of the art in silico toxicological tools including scientific data handling approaches. In this context, the incumbent is responsible for the development of methods and software tools for understanding biological data, which are aligned with user requirements from SRA business units. The incumbent will ensure the scientific integrity of JTIs in silico toxicological tools while testing and validating the tools to verify the correctness of scientific data handling, search engines, workflows, and predictive models. The incumbent will contribute to the SRA digitalization initiative interacting with end users and suppliers, as necessary.
The incumbent supports the training activities of other relevant internal stakeholders and actively contributes to the external communication for example in publications, scientific conferences or in meetings with their expert network. The incumbent will provide project management support to aid the Toxicology team while promoting Agile ways of working for incorporation into procedures and processes.

**Position**:

- **Risk assessment and in silico Data handling and analysis**

Contribute to toxicological risk assessments of flavor substances, tobacco ingredients, NTM ingredients, packaging ingredients, and other substances used in the manufacture of JTI products to ensure the scientific defensibility of products worldwide.

Identify and process relevant safety datasets (internal and external/new and existing) and scientific resources for computational predictive methods to fill data gaps and employ evidence toolkits.
- **In Silico Tools and data handling - Development**
- **SRA (Scientific Regulatory Affairs) Digitalization**

Contribute to developing and aligning a digitalization agenda to reinforce the SRA digital landscape, aiming to integrate new and existing scientific data and computational methods to support pipeline programs and platform technology to ease end-user adoption.
Contribute in the transition to NGRA, including handling and integration of NAMs data, ensuring proper documentation, and playing a key role in leveraging applied computational literacy within the team.
- **Product Compliance and External Engagement**

Support toxicology team members to meet regulatory requirements and submission deadlines with the provision of data for use in toxicological prediction tools, but not limited to, cheminformatics, exposure modeling, bioinformatics, and advanced database searches. Communicate results efficiently and effectively ensuring appropriate documentation and filing of data and/or reports.

Represent JTI at meetings with external experts in the area of bioinformatics. Actively contribute to publications and conferences. Closely monitor competitor activities and support the development of relevant company positions.
- **Project Management**

Support toxicology team members with project management, while promoting Agile ways of working for incorporation into procedures and processes.

**Requirements**:

- University degree in Life Science, Chemistry, Toxicology, Cheminformatics, Bioinformatics, or in a related field. Degree or PhD in toxicology as well as ERT (European Registered Toxicologist) or DABT (Diplomate of the American Board of Toxicology) certification is a plus
- 3-5+ years of relevant experience dealing with chemical structures and chemical data in academia or industry
- Experience with various computational toxicology approaches including, but not limited to predictive QSAR models for physical/chemical properties and human health toxicological endpoints, such as EPI Suite or the OECD QSAR Toolbox
- Knowledge of emerging toxicological and risk assessment technologies, applied computational methods, exposure modeling, alternative in vitro exposure systems, is a plus
- Expertise in data handling methods related to toxicological risk assessment in a regulatory context. Experience with data-driven research and tools in a regulated environment
- High degree of flexibility, project management, agility, and motivation as well as good analytical skills and a problem-solving mindset
- Strong interpersonal skills with the ability to work independently and cross-functionally in expert teams to support Next Generation Risk Assessment (NGRA)
- Experience in developing and delivering training is preferable
- Excellent English communication skills (both written and oral), further language skills would be