Postdoc Position in Quantitative Biology

vor 2 Monaten


Basel, Schweiz Universität Basel Vollzeit

The Department of Biomedicine is a joint effort between the University of Basel and the University Hospitals Basel. It unites basic and clinical scientists to advance our understanding of health and disease and to develop pioneering therapies benefiting the lives of patients in areas of unmet need. With more than 70 research groups and 800 employees, the Department of Biomedicine is the largest department at the University. We are located in the heart of Basel at 6 different locations. Be part of our future
The mission of the group is to understand fundamental mechanisms regulating short
- and long-term metabolic adaptation to genetic and chemical perturbations to find new and unconventional therapeutic strategies, ranging from antibacterial to anticancer drugs. To this end, we develop new ways to combine state-of-the-art technologies in metabolomics with mathematical modeling.

**Your position**
- Adapting existing and possibly developing improved experimental protocols for the high-throughput metabolomics analysis of drug-perturbed cells.
- Unravel the hidden potential of apparently inactive molecules in interfering with cellular metabolism.
- Support and preparation of scientific reports and journal articles

**Your profile**

Essential:

- PhD in (Bio)Physics, (Bio)engineering, Systems Biology, Bioinformatics/Computational Biology, or related fields.
- Solid experience in data analysis
- Experience with programming language (e.g. Matlab, R or Python) Motivation to work in an international research environment

Highly desirable:

- Experience in kinetic modeling and/or hands-on laboratory experience
- Good communication skills
- Interest in mathematical modeling of metabolic and regulatory/signaling network

**We offer you**
- You will have access to state-of-the-art research equipment in metabolomics and computational biology.
- You will work in a dynamic and highly interdisciplinary team including computer scientists, experimentalists.
- You will be involved in cross-disciplinary collaborations and have training opportunities to further develop and grow your scientific interests.
- Opportunity to work in close contact with other basic
- and clinical-research groups at the Department of Biomedicine and the Biozentrum in Basel
- Support from highly competent, experienced team members and potential to lead projects with a high degree of academic freedom

**Application / Contact**

Key References:
Ortmayr, K., de la Cruz Moreno, R. & Zampieri, M. Expanding the search for small-molecule antibacterials by multidimensional profiling. Nat Chem Biol 18, 584-595 (2022)
Anglada-Girotto, M., Handschin, G., Ortmayr, K. et al. Combining CRISPRi and metabolomics for functional annotation of compound libraries. Nat Chem Biol 18, 482-491 (2022)
Zampieri, M., Hörl, M., Hotz, F. et al. Regulatory mechanisms underlying coordination of amino acid and glucose catabolism in Escherichia coli. Nat Commun 10, 3354 (2019)
Øyås O., Borrell S., Trauner A., et al. Model-based integration of genomics and metabolomics reveals SNP functionality in Mycobacterium tuberculosis. PNAS 117 (2020)
Campos A. and Zampieri M. Metabolomics-Driven Exploration of the Chemical Drug Space to Predict Combination Antimicrobial Therapies. Molecular Cell 74, 1291-1303 (2020)

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