Research Associate

vor 2 Monaten


Zurich, Schweiz Institute of Pharmacology and Toxikology, Group of Prof. Gerald Schwank Vollzeit

Institute of Pharmacology and Toxikology, Group of Prof. Gerald Schwank_
**Research Associate / Research Assistant**
**80-100 % **:The group of Prof. Schwank is working on translational genome editing and cell-based therapies. Within the group, we are working towards generating cell-based therapies directly in the patient using RNA-based technologies. Specifically, we aim to generate CAR cell therapies in situ for the treatment of cancer.

**Your responsibilities**: As a Research Associate you will contribute to the development of new in patient generated cell-based immune therapies. You will be responsible for all tasks related to scientific research conducted in the laboratory, including designing, planning, performing, analyzing, and reporting experimental studies.

You will be responsible to:

- Independently execute, monitor and coordinate in vivo studies.
- Perform in vivo study functions including animal dosing, bleeding, tissue harvesting, imaging and necropsy.
- Generate data, contribute to study designs, interpret results, and maintain accurate electronic laboratory notebook (ELN) records.
- Work with team members to perform ex vivo analyses, organize and prepare test articles/cell lines/tissue samples for in vivo studies.
- Present study data in cross-functional project meetings
- Contribute to solving technical problems in a practical and rational manner
- Contribute to a positive and exciting work environment

**Your profile**: We are seeking for a highly motivated research associate. Applicants should hold a Master's degree in biological engineering, veterinary medicine, biology, or a related field or Bachelor's degree/apprenticeship with several years of experience.

You should have
- A robust expertise with intravenous (IV), intraperitoneal (IP) and subcutaneous (SQ) injections of laboratory rodents. Strong tail vein intravenous dosing expertise is required
- Robust proficiency with rodent necropsy, tissue collection/processing for flow cytometry analysis.
- Experience working with tumor models and humanized mouse models is desirable.
- Experience with retro-orbital dosing and orthotopic tumor engraftment is a plus.
- Experience with cell culture of immortalized and primary cells.
- Experience with ex vivo experimental tools such as FACS, ELISA, RT-PCR etc. is a plus.
- Excellent organizational skills and proficiency in multitasking.
- Experience maintaining an electronic laboratory notebook and following protocols, familiarity with programs such as Excel and Prism for data entry.
- The applicant should have a collaborative spirit, should be highly motivated, and dedicated to perform research of the highest quality

**What we offer**: We offer varied and interesting work in an inspiring and socially relevant environment.

Diversity and inclusion are important to us.

**Place of work**: University of Zurich, Campus Irchel, Winterthurerstr. 190, 8057 Zurich

**Start of employment**: Immediate start or to be mutually agreed.


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