Principal Scientist Bas Cellular Analytics
Vor 3 Tagen
The Bioanalytical Science Department (BAS) Research and Development is currently seeking a Principal Scientist with a solid background and expertise in developing cellular and molecular-based assays to determine potency and cytotoxicity in a variety of therapeutic proteins.
In this position, extensive knowledge in cell biology, signal transduction and bioassay principles are required to support the team in developing cell-based methodologies to accomplish short-, mid
- and long-term project goals. Scientific enthusiasm, creativity, hands-on expertise, and goal-oriented mindset is essential for execution of organizational deliverables to project timelines.
Key Responsibilities Include:
- Responsible for providing critical cell-based assay expertise to complement the existing in-house product characterization team and delivering on cell-based functional assays as per project requirements using appropriate state of the art technology platforms
- Responsible for defining phase-appropriate bioassay strategies for product development. In addition, enabling characterization of products and link to the targeted mechanism of action (MoA) using design of experiment (DOE) and analytical QbD
- Responsible for executing, developing, optimizing and qualifying functional assays (cellular and molecular-based assays as appropriate) to mimic _in vivo_ product efficacy and/or safety
- Actively contribute to new methodologies and next generation technologies by keeping abreast of next generation platforms, identifying, evaluating, and implementing appropriate innovative approaches with a focus on potency assays
- Responsible for supervising and coaching junior scientist in performing and developing cell-based methods
- Act as BAS Subject Matter Expert (SME) relating to cellular and biological-related assays, provide scientific input to multiple projects and technical teams
- As a functional assay SME, ensure successful transfer of assays and knowledge to contract labs/CROs including troubleshooting issues relating to challenges in setting up the assays at the CRO labs
- Author lab procedures, protocols, reports and SOPs for internal and/or external partners. Present at internal and external seminars and conferences.
- Collaborate with Group members and cross-functional teams to support product characterization, process development, and other studies. Ensure close collaboration with other local and global CSL functions across the R & D network.
Qualifications, Skills and Experience:
Ph.D. in Cell Biology, Biochemistry, Biological Sciences or related fields with +3 years of biopharmaceutical industry experience in the field of cellular and molecular assay development for product development
- Excellent understanding of biological and cellular mechanism of actions (MoA) of different biomolecules (antibodies, therapeutic proteins) for the development of fit-for purpose assay to determine product safety and efficacy
Hands-on experience in a wide range of biological and immunological techniques (e.g. FACS, chemiluminescence, fluorescence, FRET, LANCE, FP) as well as affinity-based techniques (SPR, BLI)
- A solid understanding of current statistical approaches and data analysis packages to evaluating potency results (e.g. GraphPad Prism, SoftMax Pro, JMP, Matlab, PLA).
- Hands-on experience in good cell culture practices such as excellent aseptic techniques, isolating, culturing and troubleshooting as required. Experience working with BSL2 level biological agents.
- Good understanding of scientific process, including hypothesis development and experimental design (DoE) with an ability to capture, design and record complex scientific data accurately and reliably
- Proficient English verbal and written communication skills with ability to work independently as well as in a team environment
**Our Benefits**:
We encourage you to make your well-being a priority. It’s important and so are you. Learn more about how we care at CSL.
**About CSL Behring**:
CSL Behring is a global leader in developing and delivering high-quality medicines that treat people with rare and serious diseases. Our treatments offer promise for people in more than 100 countries living with conditions in the immunology, hematology, cardiovascular and metabolic, respiratory, and transplant therapeutic areas. Learn more about CSL Behring.
**We want CSL to reflect the world around us**:
As a global organisation with employees in 35+ countries, CSL embraces diversity and inclusion. Learn more about Diversity & Inclusion at CSL.
**Do work that matters at CSL Behring**:
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