Postdoc or Research Associate
vor 2 Wochen
Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Zurich_
**PostDoc or research associate (M.sc.) for the Project: Gene Engineering Macrophages for Cancer Immunotherapy**
**100 % **:We have two major focus in the laboratory. In fact, the laboratory is internationally recognized for its work on HIV pathogenesis. Within the context of this work, we have come up with genetically engineered macrophages for the treatment of cancer. We invested a lot of R&D into the cancer project over the last years with the medium term goal of a clinical phase I trial.
The laboratory of Prof. Roberto Speck is very well embedded in the research place of Zurich and benefits from its unique scientific richness. Notably, we have very active international collaborations for the gene engineering part (Prof. Michael Pepper, University of Pretoria (SA) and Prof. Karl-Heinz Krause, University of Geneva (CH)), and for immunotherapy (Prof. Giuseppe Pantaleo, University of Lausanne). Specific for the cancer project, we have as advisors Prof. Andreas Wicki (University hospital Zurich) and Prof. Beat Thürlimann (Canton hospital St. Gallen) and are currently further expanding the network and activley seeking for collaborations. The project itself was also awarded with Venture Kick Stage I and II.
The laboratory is well financed by various foundations, among others by the Swiss National Science, Swiss Vaccine Institute, the VonTobel Foundation, the project itself is financed via Innosuisse and the USZ Foundation.
**Your responsibilities**: We are looking for a highly motivated person at PostDoc level or research associate (M.sc.) for our project: "Genetically Engineering Macrophages for Cancer Immunotherapy". Thus this position is dedicated to establish a humanized mouse model for triple negative breast cancer and subsequently characterize genetically engineered macrophages as a cell based immunotherapy. Therefore hands on experience with tumor mouse models is mandatory. In addition, the scientist would assist in the molecular and cell biology work coming up in the context of this project. Please note, the project is a high risk, high gain project with the medium to longterm goal of introducing the macrophage based therapy to the clinics.
**Your profile**: Mandatory:
- PhD or M.sc. in molecular cell biology, immunology, cancer biology and immunotherapy or M.sc. with several years hands on experience in cancer mouse models
- Expert on tumor microenvironment ideally on tumor associated macrophages
- Hands on experience with in vivo xenograft cancer models ideally with breast cancer models in humanized mice.
- LTK1 or FELASA B
- Experience in molecular cell biology and cell culture techniques.
- Multi-parameter flow cytometry
Optional:
- Immunhistochemistry
- In vivo imaging
- Experience in viral vectors for gene therapy/immunotherapies and transduction of immune cells
**What we offer**: The University Hospital of Zurich offers a future-oriented work environment with attractive employment conditions. The position is financed by third-party funds and currently intended for 18 months, but prolongation is possible.
**Place of work**: University Hospital of Zurich - Lab is located in Wagistr.18, 8952 Schlieren
**Start of employment**: 01. October 2023
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