Principal Associate
Vor 5 Tagen
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Principal Associate / Scientist for Large Molecule Bioanalytical Assay development using LC-MS, Basel-StadtClient:Location:Job Category:Other
Job Reference:Job Views:15
Posted:06.03.2025
Expiry Date:20.04.2025
Job Description:The Position
In Roche’s Pharmaceutical Research and Early Development organisation (pRED), we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicines. Together, we create a culture defined by curiosity, responsibility and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed.
This position is located in Basel, in a chapter within the Pharmaceutical Sciences (PS) function, where the development of regulatory compliant assays for Biomarkers and Bioanalytics is a primary focus. We closely collaborate with our therapeutic areas and functions to convert hypotheses into innovative therapeutics.
Job mission
As a Principal Associate / Scientist in the area of Large Molecule Quantitative Bioanalytics and Biomarkers, your main responsibilities are the development and application of novel LC-MS methodologies to support non-regulated preclinical studies and to drive scientific innovation in the field. You work with other scientists and associates in a matrix organization and inspire others with your technological insights and creative ideas.
Your impact
You are an expert in LC-MS technologies, scout innovative approaches and new applications for the quantitative analysis of various and novel Large Molecules that are developed as Therapeutic drugs (antibodies) and protein biomarkers.
You have demonstrated ability to develop, troubleshoot and validate complex highly sensitive LC-MS/MS and LC-HRMS assays for quantitation of Protein drugs and Biomarkers in biological matrices, including knowledge of in silico tools for identification of proteotypic peptides and deconvolution of HRMS spectra.
You have hands-on experience in the development of hybrid LC-MS/MS and LC-HRMS quantitative assays, including technologies for immunoaffinity capture.
You inspire other scientists and associates and train them in the application of new technologies in the area.
You are keen to develop and troubleshoot methods for the pre-clinical and clinical development of drugs and biomarkers for other modalities, Small Molecules or Oligonucleotides.
Your profile
MSc in Biochemistry, Chemistry and Pharmaceutical technologies, Analytical Chemistry or similar.
4+ years experience in development, validation and application of LC-MS assays for the measurement of therapeutic antibodies and protein biomarkers in biological fluids. Previous experience in quantitative LC-MS method development for small molecules and oligonucleotides will be a plus.
Ability to think unconventionally, applying scientific rigor in the evaluation and development of new technologies to support all current and emerging modalities.
High spirit of collaboration and ability to work in a highly self-managed manner in an agile matrix team with sense of urgency and ability to deal with complex situations.
You exhibit a growth mindset. You ask for feedback and act on it. You embrace opportunities to gain new skills and perspectives and provide honest feedback to others to help them grow.
You are able to radically simplify and prioritize for impact. You invest your time in things that accelerate progress for patients. You stop doing things that do not.
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