Cell Therapy Process Development Scientist 80-100%

Vor 4 Tagen


Basel, Schweiz Innovation Office University of Basel Vollzeit

Tissue Engineering Cluster of University Hospital Basel

The Department of Biomedicine is a joint effort between the University of Basel and the University Hospitals Basel. It unites basic and clinical scientists to advance our understanding of health and disease and to develop pioneering therapies benefiting the lives of patients in areas of unmet need.

With more than 70 research groups and 800 employees, the Department of Biomedicine is the largest department at the University. We are located in the heart of Basel at 6 different locations. Be part of our future

Intervertebral Disc Research Unit (Dr. Olga Krupkova) at University Hospital Basel is seeking a translational research specialist to work on advancing iMODICel, an innovative cell therapy targeting chronic low back pain.

Low back pain is one of the most disabling conditions worldwide with significant socioeconomic impact. Vertebral endplate bone marrow lesions ('Modic changes') are a common source of chronic low back pain in affected patients. However, no disease-modifying treatment exists for Modic changes. Over the past decade, our partners (Prof. Stefan Dudli, University of Zurich) have uncovered the molecular mechanisms underlying Modic changes and developed an approach for a targeted therapy using a cell therapy (iMODICel). This project is strictly translational, aiming to bring iMODICel towards a first-in-human trial. Within this context, we are seeking a skilled and motivated translational scientist to join our team.

Your positionResponsibilities

The successful candidate will play a pivotal role in translational activities related to the development of cell therapies in compliance with good manufacturing practice (GMP) standards. Key responsibilities include:

  • Implementation and validation of GMP manufacturing protocols and quality control (QC) measures
  • Design and execution of laboratory tasks including cell culture, QC assays, and material preparation
  • Data management and protocol documentation according to GMP requirements
  • Integration of new equipment/technologies and operations into GMP
  • Collaboration with cross-functional teams to troubleshoot and optimize production processes
  • Support the preparation of data and documentation for regulatory submissions
Your profileWe Are Looking For a Candidate With
  • A university degree in Biomedical sciences or related Life sciences field
  • Strong technical expertise in laboratory techniques including cell culture, QC assays, and material preparation
  • Extensive experience in designing, interpreting, and documenting screening, optimization, and validation experiments
  • Passion for translational research, with the ability to independently navigate challenges and contribute innovative solutions
  • Strong collaboration skills to work effectively with internal and external partners
  • An entrepreneurial mindset
  • Excellent spoken and written English communication skills
We offer you
  • A unique opportunity to co-develop a therapeutic for one of the most disabling conditions worldwide
  • Work in a high-level tissue engineering laboratory at the forefront of ATMP development
  • Interesting and diverse tasks within a dynamic and supportive research group
  • Access to an interdisciplinary research community
  • Employment on renewable 1-year contracts, up to a maximum of 4 years
  • Flexible working conditions to support work-life balance
Application / Contact

Join us in advancing iMODICel, a pioneering cell therapy addressing one of the leading causes of disability worldwide.

If you meet the requirements, please send your documents (cover letter, CV, list of publications, reference letters, etc) to olga.krupkova@unibas.ch by January 31st 2025.

For more information, please contact Dr. Olga Krupkova. We look forward to receiving your application.

www.unibas.ch

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