Scientist, Computational Medicinal Chemistry
vor 22 Stunden
Overview We are seeking a highly motivated, creative Computational Medicinal Chemist to support drug discovery programs. The successful candidate will operate at the interface of computational chemistry and medicinal chemistry, serving as an embedded, project-facing contributor within lead identification and lead optimisation (LI/LO) teams. The position will also involve contributions to earlier drug discovery phases and the development of computational tools with direct application in medicinal chemistry. This role is strongly project-driven: you will apply computational approaches to directly inform compound design, optimisation, and decision-making, working closely with multidisciplinary teams in chemistry, biology, and data science. The position offers the opportunity to make a tangible impact on the design and optimisation of novel chemical matter, leveraging the company’s core expertise in degrader discovery. Responsibilities Serve as a core computational contributor on project teams, supporting lead identification, hit-to-lead, and lead optimisation through structure- and ligand-based design. Apply and integrate computational techniques such as molecular docking, ligand-based design, diversity and conformational analyses, molecular modelling, and related approaches to guide SAR exploration and compound optimisation. Contribute to the design and prioritisation of project-relevant compound libraries and collections in close collaboration with medicinal chemists. Communicate computational results clearly and effectively to cross-functional teams, translating analyses into actionable medicinal chemistry guidance. Contribute to the development and continuous improvement of computational workflows, tools, and best practices within the realm of computational medicinal chemistry. Qualifications PhD in computational chemistry, chemistry, biophysics, or a related scientific discipline with a strong computational focus. 1-4 years of Postdoctoral training and/or relevant industry experience in pharmaceutical or biotech drug discovery. Demonstrated application of ligand- and structure-based design approaches in small-molecule drug discovery projects. Working knowledge of medicinal chemistry and preclinical drug design in the context of compound optimisation, including SAR development, ADME considerations, and multiparameter optimisation. Solid understanding of protein–ligand interactions and structure-based compound optimisation strategies, along with hands‑on experience with multiple core computational techniques in ligand- and structure-based drug design. Hands‑on experience with molecular visualisation and modelling software such as PyMOL and Schrödinger suite for structure analysis and drug design applications. Proficiency in Python and cheminformatics toolkits with practical application of these skills for scientific scripting, data analysis, workflow development, and management and analysis of large chemical datasets. Proficiency in statistical analysis and data visualisation tools (e.g. Jupyter notebooks, Spotfire). Familiarity with machine‑learning approaches for small-molecule activity and ADME property prediction, and experience applying model outputs in a medicinal chemistry or project context. Experience working effectively within multidisciplinary project teams and communicating computational results to non‑computational scientists. Strong scientific writing skills and track record of publications in peer-reviewed journals. Experience in targeted protein degradation is a plus. #J-18808-Ljbffr
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Scientist, Computational Medicinal Chemistry
vor 22 Stunden
Basel, Schweiz Monte Rosa Therapeutics Inc. VollzeitOverview We are seeking a highly motivated, creative Computational Medicinal Chemist to support drug discovery programs. The successful candidate will operate at the interface of computational chemistry and medicinal chemistry, serving as an embedded, project-facing contributor within lead identification and lead optimisation (LI/LO) teams. The position will...
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Scientist, Computational Medicinal Chemistry
Vor 2 Tagen
Basel, Basel-Stadt, Schweiz Monte Rosa Therapeutics VollzeitWe are seeking a highly motivated and creative Computational Medicinal Chemist to support discovery programs. The successful candidate will operate at the interface of computational chemistry and medicinal chemistry, serving as an embedded, project-facing contributor within lead identification and lead optimisation (LI/LO) teams, with additional involvement...
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Vice President, Medicinal Chemistry
vor 1 Woche
Basel, Schweiz LifeMine Vollzeit**Our Company** **Summary** We are seeking an accomplished, and passionate drug hunter to lead our expanding Medicinal Chemistry Team across multiple sites. The successful applicant will have a proven track record of creativity, innovation, and leadership across all facets of drug discovery, with a broad and deep knowledge of Medicinal and Synthetic...
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Basel, Basel-Stadt, Schweiz Ridgeline Discovery GmbH VollzeitSERAC Biosciences AG is looking for a Principal Scientist/Associate Director, Medicinal Chemistry. Ridgeline Discovery, a Versant Ventures Discovery Engine, creates and operates Versant-financed innovative biotech companies in partnership with entrepreneurs, industry, and leading academics across Europe. In recent years, Ridgeline has assembled an...
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Computational Medicinal Chemist: Lead Discovery
vor 21 Stunden
Basel, Schweiz Monte Rosa Therapeutics VollzeitA biotechnology company in Basel is seeking a motivated Computational Medicinal Chemist to support drug discovery programs. The role involves applying computational techniques to optimize compound design and collaborating with multidisciplinary teams. Applicants should hold a PhD and have 1-4 years of relevant experience in pharmaceutical or biotech sectors....
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Computational Medicinal Chemist
vor 22 Stunden
Basel, Schweiz Monte Rosa Therapeutics Inc. VollzeitA biotech firm based in Basel is seeking a highly motivated Computational Medicinal Chemist. In this role, you will leverage your expertise in computational chemistry to drive drug discovery initiatives, supporting lead identification and optimization efforts. The ideal candidate holds a PhD and has 1-4 years of relevant industry experience. You will work...
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Basel, Schweiz The Computational Chemistry List VollzeitCCL 25.02.24 Postdoctoral Position, Chemistry Department, Uni Basel, Switzerland (Group Meuwly)Applications are invited for postdoctoral positions in theoretical and computational chemistry in the group of Markus Meuwly, Department of Chemistry, University of Basel, Switzerland. The initial appointment is for one year, with the possibility to renew for a...
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Principal Scientist/
vor 1 Woche
Hochbergerstrasse C Basel City, Basel, Switzerland Ridgeline Discovery VollzeitSERAC Biosciences AG is looking for a Principal Scientist/ (Associate) Director, Medicinal Chemistry. Ridgeline Discovery, a Versant Ventures Discovery Engine, creates and operates Versant-financed innovative biotech companies in partnership with entrepreneurs, industry, and leading academics across Europe. In recent years, Ridgeline has assembled an...
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Associate Director
vor 1 Tag
Basel, Schweiz Skyhawk Therapeutics Europe GmbH VollzeitTasks - Act as a leading scientist on one or more discovery research projects with the ability to drive conclusive results - Leverage expertise in synthetic organic and medicinal chemistry to drive SAR optimization cycle to further pipeline goals. - Effectively manage work conducted at global CROs - Participation in scientific review and assessment of...
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Computational Scientist
vor 1 Woche
Basel Headquarter, Schweiz Roche VollzeitAt Roche you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections, where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally. This is how we aim to prevent, stop and cure diseases and ensure...
