Intern - Organoid Phenotyping, Institute of Human Biology

vor 4 Wochen

Basel, Basel-Stadt, Schweiz F. Hoffmann-La Roche AG Vollzeit

Roche fosters diversity, equity and inclusion, representing the communities we serve. When dealing with healthcare on a global scale, diversity is an essential ingredient to success. We believe that inclusion is key to understanding people's varied healthcare needs. Together, we embrace individuality and share a passion for exceptional care. Join Roche, where every voice matters.

The Position

In Roche Pharmaceutical Research and Early Development Organization (pRED) we believe the rapid advances in science, technology, digital and big data are our greatest opportunity to rethink how we tackle some of the world's toughest unmet health care needs and to have an even more profound impact on patients and society.

At pRED we are united by our mission to transform science into medicines. Together we create a culture defined by curiosity, responsibility and humility where our amazing people are empowered and inspired to bring forward amazing innovation at speed. Within pRED, the goal of the Institute of Human Biology (IHB) is to disrupt the traditional drug discovery process through innovative, big and bold ideas focused on advancing our ability to use more predictive human model systems.

You will work on a collaborative project between Institute of Human Biology at pRED and Genentech, exploring how human diversity is reflected in drug response. In your role, you will support establishment of epithelial cultures from patient-derived organoids for drug screening and use cutting edge methods, such as high content imaging to characterize patient diversity at various biological scales. For this project, you will join the Organoid Phenotyping platform of the IHB, giving you a unique opportunity to apply various automation techniques to complex human model systems. Throughout the project you will be mentored by experts in the field of organoid biology, allowing you to expand your skills and knowledge. You will plan, execute, and document experiments, analyse data, and present results in a team spanning Europe and the US.

Your impact:
  • Cell culture of organoids, assume responsibility for the accuracy, quality, and timeliness of organoid culture activities.
  • Develop and implement SOPs for automated culture of many intestinal organoid lines in collaboration with scientists at IHB
  • Develop and implement SOPs for toxicity assays in adult intestinal stem cells either in transwell format or in matrigel embedded organoids in collaboration with scientists at IHB
  • Operate a robotic liquid handling platform for cell culture and assay execution.
  • Communicate with relevant stakeholders and supervisors about the status of the projects and of critical problem areas.
  • Present your results to scientists at IHB and Genentech.
  • Document and report all relevant laboratory processes.
Your Profile:
  • You are currently enrolled in a Master's degree program or a pursued your Master's degree not longer than 12 months prior to the start date in life sciences or a related field
  • Strong laboratory skills, cell culture experience is essential
  • Experience in BSL2 cell culture of advantage
  • Experience with epithelial organoid culture (colon, small intestine) of advantage
  • Excellent written and verbal communication skills
  • Ability to work independently and as part of a team
  • Strong analytical and problem-solving skills
  • Affinity for data analytics
  • Experience with microscopy of strong advantage
  • Experience with image analysis of advantage
  • Basic knowledge of Python of advantage

The preferred start date of the internship is as soon as possible, for 6 months.

Application:

Applications need to include a CV and a motivation letter, both merged in one document. If you are currently studying, please include a valid certificate of enrollment as well.

Due to regulations, non-EU/non-EFTA citizens without either a B permit with work permit or a C permit need to provide a certificate of enrollment, as well as a certificate from the university stating that an internship is mandatory and stating the length.

We are excited to see your application

Who we are

At Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we've become one of the world's leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.

Basel is the headquarters of the Roche Group and one of its most important centres of pharmaceutical research. Over 10,700 employees from over 100 countries come together at our Basel/Kaiseraugst site, which is one of Roche`s largest sites. Read more.

Besides extensive development and training opportunities, we offer flexible working options, 18 weeks of maternity leave and 10 weeks of gender independent partnership leave. Our employees also benefit from multiple services on site such as child-care facilities, medical services, restaurants and cafeterias, as well as various employee events.

We believe in the power of diversity and inclusion, and strive to identify and create opportunities that enable all people to bring their unique selves to Roche.

Roche is an Equal Opportunity Employer.

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