position in immune cell biology

Particularité

The laboratory of Prof. Jens Stein at the Department of Oncology, Microbiology and Immunology (OMI) of the University of Fribourg (UNIFR)/Switzerland is looking for a motivated and skilled candidate to join our team working on distinct aspects of CD8+ T cell biology in mouse models of infection, including their interactions with lymphoid and non-lymphoid tissue microenvironments. Adaptive immune reponses are initated in lymphoid tissue such as lymph nodes, from where effector T cells spread out to infiltrate non-lymphoid tissue, where they eliminate infected target cells. After clearance of viral reservoirs, tissue-resident memory cells reside in these organs for prolonged periods of time as protective force. Our recent data have uncovered that tissue-specific properties cooperate with biochemical signals to influence the surveillance mechanisms of local immune cells, in a process involving nuclear mechanosensing. Here, we propose to further examine this phenomenon during tissue-immune cell crosstalk using novel genetic tools and innovative in vivo and ex vivo functional approaches, including spectral flow cytometry and RNA sequencing.

Domaine d'activité

Techniques applied during Ph.D.
Cutting edge cellular and molecular immunology techniques including multiplex flow cytometry, single cell RNA sequencing, intravital imaging, transgenic mouse models, ex vivo functional assays.

Exigences

• Master in Science with strong motivation to work in immunology, cell biology and imaging
• Good work organization, curious, creative, goal-oriented

Exigences linguistiques

autre: English

Date d'entrée en fonction:

date à convenir

Renseignements:
Prof. Jens Stein

W:

Date limite de réception des offres:

Adresse d'envoi:
Interested applicants should send a letter of motivation, complete CV and a list of referees to Prof. Jens Stein