Lab Scientists in LC-MS based Proteomics

Vor 7 Tagen

Basel, Basel-Stadt, Schweiz Roche Vollzeit

The Position

In Roche'sPharmaceutical Research and Early Development organization (pRED), we make transformative medicines for patients in order to tackle some of the world's toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicines. Together, we create a culture defined by curiosity, responsibility and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed.

360 Labs Initiative at a Glance

The 360 Labs are a new capability that is currently being built up within the Pharmaceutical Research and Early Development organization (pRED). The primary mission of this effort is to provide greater access and support for the use of cutting-edge biomedical research technologies by scientists across our discovery portfolio.

Operating as an integrated ecosystem, the 360 Lab environment will deliver core scientific technologies, expertise and enabling activities, as well as facilitate knowledge sharing and learning experiences in close collaboration with our therapeutic areas and functions. Together, these efforts will serve to increase the speed, enhance the robustness and improve the sustainability of our exploratory research and early discovery activities.

We are currently recruiting scientific professionals with varied backgrounds in Flow Cytometry, Genomics, Proteomics, Histopathology and Microscopy / Imaging. In these new roles, your collaborative mindset is as valued as your scientific expertise. The 360 Labs are by nature a hands-on, interactive workplace where face to face presence in our labs is a priority. Our ambition is to bring to life a thriving workplace environment, acting as an highly integrated ecosystem, supporting research and development, working collaboratively, and focused on fostering excellence and sustainability.

Job Mission and Impact

The Proteomics Core Technology Platform in the 360 Labs Initiative is seeking to add to its team two lab-based scientific professionals, with a focus on LC-MS based proteomics technologies applied to drug discovery. The successful candidates will have a strong background in biochemistry as well as a high proficiency in leveraging LC-MS technologies to generate scientific insights through the development and application of investigative proteomics studies. You will work as a part of a matrix team, collaborate closely with experts from each of our therapeutic disease areas and functions and participate in the early implementation and growth of the Proteomics Core Technology Platform within the pRED organization.

Your Role and Responsibilities

Plan, design and execute hands-on, with little to no oversight, experiments to develop, optimize and implement either standard or custom LC-MS based proteomics workflows (including sample preparation, nano LC-MS/MS measurement using high-end mass spectrometry instrumentation, and data QC and processing). Provide reports, present and discuss detailed data analysis to the stakeholders in a dynamic and flexible manner. Work closely with other laboratory and bioinformatic teams across the pRED organization to optimize and analyze newly implemented and / or developed proteomics protocols. Be accountable for delivering proteomics data on time and within forecasted budget, maintenance of lab equipment and infrastructure, and ensuring compliance with local requirements. Embrace a continuous learning mindset by actively engaging with the scientific literature to stay abreast of emergent technologies/ approaches in the proteomics field.

Your Profile

Required

A BS degree or MS degree in Biology, Biochemistry or related field, with respectively 5-7 or 3-5 years research experience in proteomics is required. A graduate degree (PhD with 1-3 years postdoctoral and/or pharmaceutical R&D experience) is highly desirable. A skilled experimentalist with the aptitude to design complex studies including hands-on expertise in nano liquid chromatography mass spectrometry-based proteomics, along with a strong proficiency in the operation of Orbitrap (Exploris, Tribrids, and/or Q Exactives) and ion mobility (timsTOF, FAIMS) systems. Exceptional competency in the required sample preparation methods for various quantitative approaches label-free DIA, TMT, SILAC) and acquisition strategies such as data-independant and -dependant acquisition (DIA, DDA), and targeted approaches such as parallel reaction monitoring (PRM) is required. In-depth knowledge in the development and implementation of methods for Data-Independent Acquisition (DIA) mass spectrometry. Familiarity with the databases, software tools and data visualization approaches commonly used in processing, storing and interpreting proteomics data.

In addition to your scientific expertise and critical technical skills we are looking for candidates who are:

Curious with a growth mindset, resourceful and flexible in problem solving, have excellent organizational skills, and can think outside the box and have a demonstrated ability to implement new ideas in a fast-paced research environment; Excellent communicators with a high fluency in English, a desire to continuously build a personal network and the ability to thrive in a dynamic, inclusive environment which gives you full accountability for your own contributions and development.

Your Location

These positions are based in Basel.

Our commitment

Roche commits to recognizing talent and aptitude. We prioritize encouraging and supporting our employees on their personal journeys by providing a safe, creative space to help them reflect, make decisions and grow in their career.

We are confident that we find the most innovative solutions by gaining different perspectives, asking and answering hard questions, and challenging the status quo. Roche embraces diversity and equal opportunityin a serious yet enthusiastic way; we are devoted to building a team that represents a range of backgrounds, perspectives, and skills. The more inclusive we are, the better our work will be.

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