Senior Research Associate or Scientist I

vor 1 Woche

Basel, Basel-Stadt, Schweiz Skyhawk Therapeutics Europe GmbH Vollzeit

Skyhawk Therapeutics, with sites in Boston and Basel, is a drug discovery and development company founded in 2018 by leading experts in small molecule therapeutics. Skyhawk is committed to discovering, developing, and commercializing small molecule therapeutics that modify RNA expression. We use our novel SkySTARTM platform (Skyhawk Small molecule Therapeutics for Alternative splicing of RNA) to develop drug candidates for some of the world's most intractable diseases including cancer, neurological conditions, and other therapeutic areas and targets previously considered "undruggable." For more information about the company, please visit our website.

Tasks

The successful candidate will have the exciting opportunity to work in collaboration with an experienced cross-functional team and external partners to advance small molecules targeting RNA for multiple indications. They will perform both basic and specialized molecular biology and biochemical techniques, as well as cell-based assays and compound testing. The candidate will be involved in establishing, maintaining and improving cutting-edge technology in a multidisciplinary environment, and will have the opportunity to support multiple stages of drug discovery, from early target assessment and /discovery to lead optimization. They will actively contribute to the innovative, open, and supportive culture at Skyhawk, and will be part of a dynamic team focused on delivering transformative therapies to patients.

  • In close collaboration with biology group leaders and scientists, design, develop, execute and analyze a variety of experiments, including but not limited to:

    - RNA/DNA isolation, electrophoresis, library preparation and sequencing

    (MiniSeq), RT-qPCR for analysis of gene expression and detection of splice

    variants;

    - Mammalian cell culture (including primary lines and iPSCs), transfection, viral

    transduction, generation of stable cell lines;

    - Cell-based assays including luminescence/fluorescence reporter assays, imaging,

    Flow cytometry, proliferation and viability assays and others;
  • Design, build, and automate protocols for use in molecular biology, genomics, next generation sequencing and cell biology applications
  • Establish new workflows and help improve efficiency in existing processes
  • Record all data and results in ELN with accuracy and responsibility in a timely manner
  • Analyze and interpret results from a variety of readouts, including DNA/RNA sequencing
  • Prepare presentations and efficiently discuss results at internal and external meetings
  • Perform and interpret database and scientific literature searches
Requirements
  • Minimum of Master degree with at least 5 years industrial experience or Ph.D. in Molecular Biology, Genomics or equivalent with in depth knowledge of RNA splicing biology strongly preferred
  • Excellent understanding of molecular biology and cellular assays is required, including design of tools (e.g., qPCR primers, splicing minigenes) and data analysis (e.g., sequence alignments). Experience generating samples and analyzing and interpreting NGS data is highly preferred
  • Solid experience with neuroscience or oncology and/or immunology assays and biology
  • Experience with preparing and presenting data summaries and progress reports in group meetings
  • Ability to think critically and manage tight deadlines. Excellent planning and organizational skills, ability to adjust plans according to priorities, ability to manage multiple tasks simultaneously and set priorities
  • Flexible, efficient and able to work independently and proactively with a problem-solving attitude
  • Ability to deliver and thrive in a timeline-driven, fast-paced biotech environment
  • Strong team player with a team-centered and positive attitude
  • Proficiency in MS Office package and GraphPad prism. Experience with other data analysis software and/or R programming are an asset
  • Fluent in English (spoken and written)

A COVER LETTER IS REQUIRED. Please explain why this job is of interest to you. Please detail your strengths and weaknesses as they pertain to the requirements and responsibilities of this position.

Please, DO NOT submit your application directly through our website.

  • Junior Research Associate

    vor 1 Woche

    Basel, Basel-Stadt, Schweiz Coopers Group AG Vollzeit

    Junior Research AssociateFor our client in Zurich we are looking for aJunior Research AssociateContract till December 2023Tasks & Responsibilities: Establish and perform in vitro characterization of the activity of novel immunotherapies (e.g. binding assay, tumor cell lysis, immune cell and reporter cell activation, proliferation, cytokine secretion) Develop...

  • Senior Principal Scientist/Associate Director

    vor 1 Woche

    Basel, Basel-Stadt, Schweiz Novartis Farmacéutica Vollzeit

    Senior Principal Scientist/Associate Director - Translational Research & Immunology %*) Job ID 395156BR Summary Location: Basel, SwitzerlandFull time, onsite, #LI-OnsiteThe Immunology Department (IMM-DA) at Novartis has a strong track record in discovery and development of novel therapies for the treatment of autoimmune and inflammatory diseases and unmet...

  • Research Scientist

    vor 1 Woche

    Basel, Basel-Stadt, Schweiz Novartis Vollzeit

    6500 That's the number of associates in the Novartis Institutes for BioMedical Research (NIBR). This division is the innovation engine of Novartis, focusing on powerful new technologies that have the potential unveil therapeutic breakthroughs for patients. Are you a curious, independent scientist eager to work on the development of the next generation of...

  • Associate Scientist

    vor 1 Woche

    Basel, Basel-Stadt, Schweiz We make it Vollzeit

    Beschreibung:We make it GmbH is a company operating nationally in Switzerland, which has a high level of competence in the personnel services sector thanks to many years of successful experience.Concentration of placement activities on the core areas of industry, technology, office/administration, engineering, pharmaceuticals and IT. We make it GmbH places...

  • Associate/scientist in Cellular Assays and

    vor 1 Woche

    Basel, Basel-Stadt, Schweiz We make it Vollzeit

    Beschreibung:We make it GmbH is a nationally active company in Switzerland with a high level of expertise in the field of personnel services thanks to many years of successful experience.Concentration of placement activities on the core areas of industry, technology, office/administration, engineering, pharmaceuticals and IT. We at it GmbH set the highest...

  • Research Associate

    vor 1 Woche

    Basel, Basel-Stadt, Schweiz Coopers Group AG Vollzeit

    Research Associate - Cancer Cell TherapyFor our international client in Basel, we are looking for a Research Associate in Cancer Cell Therapy.Responsibilities Development of pharmacodynamic (PD) assays that will provide robust and accurate measurements of drug effects in cell lines and in samples of mouse models. Implementation of biomarker assays to...

  • Research Scientist

    vor 1 Woche

    Basel, Basel-Stadt, Schweiz Novartis Vollzeit

    393013BRResearch Scientist - Immunogenicity & Mechanistic Immunology %:SwitzerlandAbout the roleLocation: Basel, SwitzerlandFulltime, Onsite #LI-OnsiteImproving and extending people's lives is what we do. It's our purpose, our calling - the summit we're always striving to reach.Your responsibilities will include: Run and execute independently in vitro...

  • Research Associate

    vor 1 Woche

    Basel, Basel-Stadt, Schweiz Coopers Group AG Vollzeit

    Research AssociateFor our client in Basel, we are looking for a Research Associate to work on genomic medicine and synthetic biology projects.The focus of this position is to contribute to experimental activities related to gene editing and RNA editing of early drug discovery phases.Responsibilities: Perform cell culture of human cells (cell lines,...

  • Research Associate

    vor 1 Woche

    Basel, Basel-Stadt, Schweiz Roche Vollzeit

    The Position In Roche ́s Pharmaceutical Research and Early Development organisation (pRED), we make transformative medicines for patients in order to tackle some of the world's toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicines. Together, we create a culture defined by curiosity, responsibility...

  • Research Associate

    vor 1 Woche

    Basel, Basel-Stadt, Schweiz CTC Resourcing Solutions Vollzeit

    Research Associate - Cancer Cell Targeted Therapy 5346Our client is a pioneer in Drug Discovery and Development and one of the frontrunners in Personalised Healthcare. As the world's largest R&D spender in the pharmaceutical and diagnostics domain, they work in a vast number of drug discovery & therapeutic areas and are highly recognized internationally. The...

  • Associate Scientist

    vor 1 Woche

    Basel, Basel-Stadt, Schweiz We make it GmbH Vollzeit

    We make it GmbH is a company operating nationally in Switzerland, which has a high level of competence in the personnel services sector thanks to many years of successful experience.Concentration of placement activities on the core areas of industry, technology, office/administration, engineering, pharmaceuticals and IT. We make it GmbH places the highest...

  • Principal Scientist I

    vor 1 Woche

    Basel, Basel-Stadt, Schweiz Novartis Farmacéutica Vollzeit

    Principal Scientist I - Toxicology %*) Job ID REQ Summary Location: Basel, SwitzerlandFull time, onsite, #LI-onsiteWe are seeking to hire a motivated candidate with a strong background in cellular and molecular immunology to join our Translational Immunology Unit in Basel within our Biomedical Research division.This is a unique opportunity to apply your deep...

  • Research Scientist

    vor 1 Woche

    Basel, Basel-Stadt, Schweiz Novartis Vollzeit

    395272BRResearch Scientist - Multimodal Data Integration :SwitzerlandAbout the roleLocation: Basel, Switzerland Full time, onsiteAt our organization, our purpose, our calling, and our ultimate goal is to improve and prolong people's lives by bringing medicines to as many individuals as possible around the globe. However, achieving this on a global scale is...

  • Associate/scientist in Protein Science

    vor 1 Woche

    Basel, Basel-Stadt, Schweiz We make it Vollzeit

    Beschreibung:We make it GmbH is a nationally active company in Switzerland with a high level of competence in the field of personnel services thanks to many years of successful experience.Concentration of placement activities on the core areas of industry, technology, office/administration, engineering, pharmaceuticals and IT. We make it GmbH places the...

  • Associate Scientist 100%

    vor 1 Woche

    Basel, Basel-Stadt, Schweiz nemensis ag Vollzeit

    For our client, an international company in Basel, we are in search for an Associate Scientist (f/m/d).Your responsibilities: Developing and executing various bioanalytical methods. Performing the methods to support manufacturing process development and characterization. Bioanalytical methods will be needed, e.g. as immunoassays (ELISA), endotoxin assays,...

  • Research Scientist Ii Mammalian Protein Expression

    vor 1 Woche

    Basel, Basel-Stadt, Schweiz Novartis Vollzeit

    394915BRResearch Scientist II Mammalian Protein Expression (6 month FTC):SwitzerlandAbout the roleLocation: Basel, Switzerland (Onsite)#LI-OnsiteTEMPORARY POSITION FOR 6 MONTHSBiomedical Research (BR) is the global pharmaceutical research organization of Novartis. With approximately 5,400 scientists and physicians around the world, our research is focused on...

  • Research Scientist

    vor 1 Woche

    Basel, Basel-Stadt, Schweiz Novartis Vollzeit

    6500 That's the number of associates in the Novartis Institutes for BioMedical Research (NIBR). This division is the innovation engine of Novartis, focusing on powerful new technologies that have the potential to help produce therapeutic breakthroughs for patients.We are seeking a highly motivated scientist with at least 3 years of experience in pre-clinical...

  • Research Associate

    vor 1 Woche

    Basel, Basel-Stadt, Schweiz Universität Basel Vollzeit

    The Biozentrum of the University of Basel is one of the leading life sciences institutes in the world. A total of 32 research groups and 500 employees investigate how molecules and cells create life, spanning the scale from atom to organism. Founded in 1971, the Biozentrum has been the birthplace of many fundamental discoveries in biology and medicine,...

  • Principal Scientist

    vor 1 Woche

    Basel, Basel-Stadt, Schweiz Novartis Vollzeit

    1 out of 10 people are suffering from immunological diseases. The Immunology Research Disease Area at the Novartis Institutes for Biomedical Research (NIBR) is investing in the discovery of novel and transformative therapies to improve the life of affected patients. As part of this effort, we are seeking an innovative and highly motivated Principal Scientist...

  • Research Associate

    vor 1 Woche

    Basel, Basel-Stadt, Schweiz Universität Basel Vollzeit

    How does life emerge from molecules and cells? This is the central question that motivates us. With curiosity and passion, we investigate the entire spectrum ranging from the atom to the organism. The Biozentrum of the University of Basel is one of the world's leading life sciences institutes. With 32 groups and 500 employees, we are a dynamic and...