Phd Thesis Project in Anaesthesiology

vor 2 Wochen


Bern, Bern, Schweiz Universität Bern Universität Bern Vollzeit

PhD Thesis Project in Anaesthesiology:

Title:
Establishing high-throughput behaviour-based screening assays for testing established and widely used anaesthetic and sedative compounds in a zebrafish in vivo model

Background


Over the past decade, compelling evidence from studies in laboratory animals and humans has demonstrated developmental neurotoxic effects of general anaesthetics and sedatives.

Such study outcomes have raised considerable concerns about administering anaesthetic agents during pregnancy and in early infancy, and significant limitations have arisen in the translation of preclinical observations into clinical practice.

Anaesthesia-induced postoperative cognitive dysfunction (POCD) is well described among older patients (>60yrs), but largely unknown in younger ones (

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