Bioassay Expert

Beschreibung:

We make it GmbH is a company operating nationally in Switzerland which, thanks to many years of successful experience, has a high level of competence in the personnel services sector.

Concentration of placement activities on the core areas of industry, technology, office/administration, engineering, pharmaceuticals and IT. We make it GmbH places the highest demands on quality, ethics and discretion.

For our client, a renowned pharmaceutical company based in Bern, we are looking for a Bioassay expert (M/F/d).

Bioassay expert (M/F/d):

Description
CSL Behring is a global biotherapeutics leader driven by its promise to save lives.

In Bern more than 1800 employees develop and deliver life-saving therapies to treat people with rare and serious medical conditions worldwide.

The Bioanalytical Science Department (BAS) Research and Development is currently seeking a Senior Scientist with a solid background and expertise in developing cellular and molecular-based assays to determine potency and cytotoxicity in a variety of therapeutic proteins.

- and long-term project goals. Scientific enthusiasm, creativity, hands-on expertise, and goal-oriented mindset is essential for execution of organizational deliverables to project timelines.

Task and Responsibilites

• Responsible for providing critical cellbased assay expertise to complement the existing inhouse product characterization team and delivering on cellbased functional assays as per project requirements using appropriate state of the art technology platforms
• Responsible for defining phaseappropriate bioassay strategies for product development. In addition, enabling characterization of products and link to the targeted mechanism of action (MoA) using design of experiment (DOE) and analytical QbD
• Responsible for executing, developing, optimizing and qualifying functional assays (cellular and molecularbased assays as appropriate) to mimic in vivo product efficacy and/or safety
• Actively contribute to new methodologies and next generation technologies by keeping abreast of next generation platforms, identifying, evaluating, and implementing appropriate innovative approaches with a focus on potency assays
• Responsible for supervising and coaching junior scientist in performing and developing cellbased methods
• Act as BAS Subject Matter Expert (SME) relating to cellular and biologicalrelated assays, provide scientific input to multiple projects and technical teams
• As a functional assay SME, ensure successful transfer of assays and knowledge to contract labs/CROs including troubleshooting issues relating to challenges in setting up the assays at the CRO labs
• Author lab procedures, protocols, reports and SOPs for internal and/or external partners. Present at internal and external seminars and conferences.
• Collaborate with Group members and crossfunctional teams to support product characterization, process development, and other studies. Ensure close collaboration with other local and global CSL functions across the R & D network.

You must have these qualifications / Expierences

• Ph.

D. in Cell Biology, Biochemistry, Biological Sciences or related fields with +3 years of biopharmaceutical industry experience in the field of cellular and molecular assay development for product development

• Excellent understanding of biological and cellular mechanism of actions (MoA) of different biomolecules (antibodies, therapeutic proteins) for the development of fitfor purpose assay to determine product safety and efficacy
• Handson experience in a wide range of biological and immunological techniques (eg. FACS, chemiluminescence, fluorescence, FRET, LANCE, FP) as well as affinitybased techniques (SPR, BLI)
• A solid understanding of current statistical approaches and data analysis packages to evaluating potency results (e.g. GraphPad Prism, SoftMax Pro, JMP, Matlab, PLA).
• Handson experience in good cell culture practices such as excellent aseptic techniques, isolating, culturing and troubleshooting as required. Experience working with BSL2 level biological agents.
• Good understanding of scientific process, including hypothesis development and experimental design (DoE) with an ability to capture, design and record complex scientific data accurately and reliably
• Proficient English verbal and written communication skills with ability to work independently as well as in a team environment

Work hours

• 41. h./ Week

Are you interested?
We are looking forward to hearing from you.

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